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Source document· February 25, 2026

TransMedics outlines 20–25% 2026 revenue growth target while advancing OCS programs and European expansion

View original at seekingalpha.com
TransMedics outlines 20–25% 2026 revenue growth target while advancing OCS programs and European expansion Earnings Call Insights: TransMedics Group, Inc…
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  • U.S. transplant revenue grew approximately 11% sequentially to $155 million

    80% confidence
  • OCS was responsible for 5,139 U.S. transplants in 2025, up from 3,735 in 2024

    80% confidence
  • Most lung transplant centers were waiting for FDA approval before launching into DENOVO program

    80% confidence
  • TransMedics continues to expect operating margins to approach 30% by 2028

    80% confidence
  • OUS transplant revenue grew approximately 33% sequentially to $5 million

    80% confidence
  • TransMedics is not seeing competitive dynamic impacting ability to execute in 2026 and beyond

    80% confidence
  • Almost 50% of the incremental investment in 2026 is driven by really 3 elements and those, by nature, are transitory

    80% confidence
  • TransMedics is laser-focused on ensuring successful execution of initiatives throughout 2026

    80% confidence
  • The makers of that styrofoam box (competitor) is refusing to randomize their technology to TransMedics in ENHANCE Part B trial

    80% confidence
  • Operating margins are expected to approach 30% by 2028

    80% confidence
  • 2026 operating margins expected to be up to approximately 250 basis points below 2025 full year levels, primarily reflecting timing and scale of investments

    80% confidence
  • Almost 50% of incremental investment in 2026 is driven by three elements that are transitory by nature

    80% confidence
  • TransMedics delivered an operating profit of approximately $21.3 million in Q4, representing approximately 13.2% of total revenue

    80% confidence
  • Operating margins are expected to be up to approximately 250 basis points below 2025 full year levels in 2026, primarily reflecting the timing and scale of investments

    80% confidence
  • TransMedics has huge opportunities ahead but also a few challenges and moving dynamics, with guidance factoring in all factors to be realistic and enable execution

    80% confidence
  • OCS was responsible for 5,139 U.S. transplants in 2025, up from 3,735 in 2024

    80% confidence
  • OCS was responsible for 5,139 U.S. transplants in 2025, up from 3,735 in 2024

    80% confidence
  • Total revenue for Q4 2025 was $160.8 million, representing approximately 32% growth year-over-year and approximately 12% sequential growth from Q3 2025

    80% confidence
  • Upcoming registry publication will demonstrate unequivocal statistical superiority in the most important outcomes after liver transplantation

    80% confidence
  • Operating margin expanded from 8.5% in 2024 to 18% in 2025

    80% confidence
  • TransMedics is not seeing competitive dynamics impacting ability to execute in 2026 and beyond

    80% confidence
  • TransMedics has huge opportunities ahead but also a few challenges and moving dynamics, which were factored into realistic guidance

    80% confidence
  • OCS Heart comprised 18% of heart transplants in 2025, up from 17% in 2024

    80% confidence
  • Operating margins expected to be up to approximately 250 basis points below 2025 full year levels in 2026, primarily reflecting timing and scale of investments

    80% confidence
  • TransMedics is just getting started and we have our sights focused on new peaks

    80% confidence
  • TransMedics has huge opportunities ahead but also faces a few challenges and moving dynamics, which have been factored into guidance

    80% confidence
  • By organ, liver contributed $127 million, heart $26 million and lung $2 million in Q4

    80% confidence
  • TransMedics delivered an operating profit of approximately $21.3 million in Q4, representing approximately 13.2% of total revenue for fourth quarter while making substantial investments to fuel growth

    80% confidence
  • Most lung centers were waiting to see FDA approval to start launching into DENOVO program

    80% confidence
  • What's coming is the unequivocal drop-the-mic statistical superiority in the most important outcomes after liver transplantation, referring to upcoming registry publication

    80% confidence
What we know · the intelligence behind this page
Live from the substrate
What we're seeing
Q4 2026 Clinical Catalyst Season: Big-Pharma Data Flow, Regulatory Milestones, and a Thin AI-Drug Fringe
October 2026 conferences (EASD, IGCS, NACFC, HFSA) are producing a dense run of late-stage readouts from Novo Nordisk, Lilly, Roche, Bayer, Vertex and Galderma. Regulatory milestones are scheduled behind them: the ivonescimab BLA PDUFA date on 2026-11-14, FDA acceptance of Roche's vamikibart BLA, and Scholar Rock's EMA resubmission. The AI-and-finance angle is peripheral. It consists of the AI-designed drug Rentosertib and QAIAx, a speculative microcap whose trial claims (the QIII pilot, anticipated 2027-01-01, and a patent update) are forecasts and filings rather than data, so they warrant skepticism.
Our read on the data ›
Signals we're tracking
EPKINLY Regulatory-Clinical Success Cascade
High probability of expanded label indications, additional combination approvals, and competitive positioning strength in follicular lymphoma market. Predicts positive commercial uptake and potential accelerated review for related indications.
Patterns we're watching ›
Where sources disagree
ING Group
Both facts record the same metric (shares_outstanding) for ING Group at the identical observation date (2025-12-31). FACT A states 2,902,437,688 shares; FACT B states 2,902 million shares (2,902,000,000). The difference is 437,688 shares (~0.015%). This is a genuine value conflict, though the discrepancy appears to result from FACT B rounding to the nearest million while FACT A provides the precise count.
We flag conflicts openly ›
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