Akari Therapeutics CEO Highlights Differentiated ADC Payload Strategy and Path Toward Clinical Development in New CEO Corner

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• Payload differentiation will become increasingly important as more cancer patients receive ADCs as front-line therapy and develop resistance to current ADC payload classes, leaving limited subsequent therapy options.

  60% confidence

• ADC-refractory patients are a significant, growing unmet need and an exclusive opportunity for Akari's novel payload, which current and most future ADCs will not be able to access.

  60% confidence

• Emerging clinical data presented at major medical conferences show that sequential ADC treatment using the same payload class does not provide benefit after relapse.

  60% confidence

• Gauging interest in the novel payload technology at conferences left him more convicted in Akari's technology, strategy and execution; PH1 generated meaningful interest and reinforced the belief that differentiated payloads will play an increasingly important role as ADC therapies evolve.

  60% confidence

• AKTX-101 is planned to advance to Phase 1 clinical development in mid-2027.

  60% confidence

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